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Save the DateDecember 1-2, 2026Charlotte, North Carolina12th Annual Regenerative Manufacturing Innovation Consortium (RegMIC) Meeting: A Roadmap for Tissue Organoids and Body-on-a-Chip Manufacturing Standards
About MOSSDOAbout RegMICAbout the RegMIC 2026 meeting
Methodology

Toward Standardization

Lung Fidelity Benchmark

Compare lung epithelial culture models with a fixed healthy human distal lung tissue reference. The benchmark reports transcriptomic proximity using PCA centroid distance, Spearman correlation, and robustness summaries across PCA preprocessing choices.

Reference anchorGSE165192-Human healthy distal lung tissue
PCA centroid distanceLower distance means closer global transcriptomic proximity
Spearman correlationHigher correlation means stronger gene-level rank similarity
Dolan-Moré profileTests whether ranking stays stable across 32 PCA preprocessing choices

User data format

Upload healthy, mock, untreated, or baseline lung epithelial culture RNA-seq data

Use CSV files where rows are genes and columns are samples. The first column must be named exactly Gene Symbol. Values should be raw counts or count-like non-negative expression values. Already z-scored or already batch-corrected values should not be used.

Gene SymbolSample_1Sample_2Sample_3
TP53120135141
EPCAM500490510
KRT8850870860

Demo database

Run the built-in lung culture fidelity benchmark

The demo compares public lung epithelial culture systems against the fixed healthy human distal lung tissue reference. It includes primary monolayers, immortalized monolayers, ALI-differentiated epithelium, bronchial organoids, and engineered airway organ tissue equivalents.

GSE165192-HumanHealthy human distal lung tissue reference
NHBE / hBEpCPrimary epithelial monolayer baselines
A549 / A549-ACE2 / Calu-3Immortalized or epithelial monolayer models
ALI-HBECsDifferentiated polarized airway epithelium
hBO3D bronchial organoid model
OTEEngineered airway organ tissue equivalent
Ready.

Standards and manufacturing partners

MOSSDO and RegMIC

Connect with the organizations advancing consensus standards, validation, and regenerative manufacturing across the PhysioVerse ecosystem.

About MOSSDO

The Microphysiological and Organoid Systems Standards Development Organization (MOSSDO) is a federally funded multi-stakeholder initiative focused specifically on establishing consensus-based standards for organoids, microphysiological systems (MPS), and body-on-a-chip technologies. MOSSDO develops frameworks for reproducibility, validation, and interoperability, enabling these platforms to be more reliably adopted across research, regulatory, and translational settings. In coordination with enabling ecosystem efforts such as PhysioVerse, MOSSDO provides the standards foundation that supports data integration, comparability, and broader field-wide adoption.

About RegMIC

The Regenerative Manufacturing Innovation Consortium (RegMIC), founded in 2014, is a national initiative that brings together stakeholders from industry, academia, and government to advance the manufacturing, scale-up, and commercialization of regenerative technologies. Through cross-sector collaboration, RegMIC addresses key challenges in translation, including process development, regulatory alignment, and the establishment of best practices across cell, tissue, and advanced in vitro systems.